chibi.gemmaanalysis.MetaLinkFinderCli.java Source code

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/*
 * The Gemma project
 * 
 * Copyright (c) 2007 University of British Columbia
 * 
 * Licensed under the Apache License, Version 2.0 (the "License");
 * you may not use this file except in compliance with the License.
 * You may obtain a copy of the License at
 *
 *       http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 * limitations under the License.
 *
 */

package chibi.gemmaanalysis;

import java.io.BufferedReader;
import java.io.IOException;
import java.io.InputStreamReader;

import org.apache.commons.cli.Option;
import org.apache.commons.cli.OptionBuilder;
import org.apache.commons.lang3.time.StopWatch;

import ubic.gemma.expression.experiment.service.ExpressionExperimentService;
import ubic.gemma.genome.gene.service.GeneService;
import ubic.gemma.genome.taxon.service.TaxonService;
import ubic.gemma.model.genome.Gene;
import ubic.gemma.model.genome.Taxon;
import ubic.gemma.ontology.providers.GeneOntologyService;
import ubic.gemma.util.AbstractSpringAwareCLI;
import cern.colt.list.ObjectArrayList;

/**
 * Run frequent itemset analysis. WARNING probably broken.
 * 
 * @author xwan
 * @version $Id$
 */
public class MetaLinkFinderCli extends AbstractSpringAwareCLI {

    /*
     * (non-Javadoc)
     * 
     * @see ubic.gemma.util.AbstractCLI#buildOptions()
     */
    private GeneService geneService = null;
    private GeneOntologyService goService;
    private ExpressionExperimentService eeService = null;
    private boolean writeClusteringTree = false;
    private boolean writeLinkMatrix = false;
    private String matrixFile = null, eeMapFile = null, treeFile = null, taxonName = null;
    private Taxon taxon = null;
    private LinkMatrix linkMatrix = null;

    @SuppressWarnings("static-access")
    @Override
    protected void buildOptions() {
        Option writeLinkMatrixo = OptionBuilder.withDescription(
                "Giving this option will generate the new link matrix, Otherwise reading the link matrix from file")
                .withLongOpt("linkMatrix").create('l');
        addOption(writeLinkMatrixo);
        Option writeTree = OptionBuilder.withDescription(
                "Giving this option will generate the new clustering tree, Otherwise reading the tree from file")
                .withLongOpt("clusteringTree").create('c');
        addOption(writeTree);
        Option matrixFileo = OptionBuilder.hasArg().withArgName("Bit Matrixfile").isRequired()
                .withDescription("The file for saving bit matrix").withLongOpt("matrixfile").create('m');
        addOption(matrixFileo);

        Option mapFile = OptionBuilder.hasArg().withArgName("Expression Experiment Map File").isRequired()
                .withDescription("The File for Saving the Expression Experiment Mapping").withLongOpt("mapfile")
                .create('e');
        addOption(mapFile);

        Option treeFileo = OptionBuilder.hasArg().withArgName("Clustering Tree File").isRequired()
                .withDescription("The file for saving clustering tree").withLongOpt("treefile").create('t');
        addOption(treeFileo);

        Option specieso = OptionBuilder.hasArg().withArgName("The name of the species").isRequired()
                .withDescription("The name of the species").withLongOpt("species").create('s');
        addOption(specieso);

    }

    /**
     * 
     */
    @Override
    protected void processOptions() {
        super.processOptions();
        if (hasOption('l')) {
            this.writeLinkMatrix = true;
        }

        if (hasOption('c')) {
            this.writeClusteringTree = true;
        }

        if (hasOption('m')) {
            this.matrixFile = getOptionValue('m');
        }

        if (hasOption('e')) {
            this.eeMapFile = getOptionValue('e');
        }

        if (hasOption('t')) {
            this.treeFile = getOptionValue('t');
        }
        if (hasOption('s')) {
            this.taxonName = getOptionValue('s');
        }
    }

    /**
     * 
     */
    void interactiveQuery() {
        BufferedReader bfr = new BufferedReader(new InputStreamReader(System.in));
        String geneName;
        int count = 0;
        try {
            // Hit CTRL-Z on PC's to send EOF, CTRL-D on Unix
            while (true) {
                // Read a character from keyboard
                System.out.println("The Gene ID: (Press CTRL-Z or CTRL-D to Stop)");
                System.out.print(">");
                geneName = bfr.readLine();
                if (geneName == null)
                    break;
                System.out.print("The Stringency:");
                String tmp = bfr.readLine();
                if (tmp == null)
                    break;
                count = Integer.valueOf(tmp.trim()).intValue();
                // Gene gene = geneService.load(Long.valueOf(geneName).longValue());
                Gene gene = geneService.findByOfficialSymbol(geneName, taxon);
                if (gene != null) {
                    System.out.println("Got " + geneName + " " + count);
                    linkMatrix.output(gene, count);
                } else
                    System.out.println("Gene doesn't exist");
            }
        } catch (IOException ioe) {
            System.out.println("IO error:" + ioe);
        }
    }

    /*
     * (non-Javadoc)
     * 
     * @see ubic.gemma.util.AbstractCLI#doWork(java.lang.String[])
     */
    @Override
    protected Exception doWork(String[] args) {
        // GraphVisualization graphVisualization1 = new GraphVisualization(new Object[0]);
        // graphVisualization1.run();
        // if(1== 1) return null;
        Exception err = processCommandLine(args);
        if (err != null) {
            return err;
        }
        try {
            eeService = this.getBean(ExpressionExperimentService.class);
            geneService = this.getBean(GeneService.class);
            goService = this.getBean(GeneOntologyService.class);
            TaxonService taxonService = this.getBean(TaxonService.class);
            taxon = taxonService.findByCommonName(taxonName);
            if (taxon == null) {
                return new IllegalArgumentException("The input species couldn't be found: " + taxonName);
            }
            StopWatch watch = new StopWatch();

            // load the link matrix
            if (this.writeLinkMatrix) {
                watch.start();
                linkMatrix = new LinkMatrix(taxon);
                linkMatrix.setGeneService(geneService);
                linkMatrix.setEEService(eeService);
                linkMatrix.setGoService(goService);
                try {
                    linkMatrix.toFile(this.matrixFile, this.eeMapFile);
                } catch (IOException e) {
                    log.info("Couldn't save the results into the files ");
                    return e;
                }
                log.info("Spent " + watch.getTime() / 1000 + "s to generate link matrix");
            } else {
                watch.start();
                try {
                    linkMatrix = new LinkMatrix(this.matrixFile, this.eeMapFile, eeService, geneService, goService);
                } catch (IOException e) {
                    log.info("Couldn't load the data from the files ");
                    return e;
                }
                watch.stop();
                log.info("Spent " + watch.getTime() / 1000 + "s to load the data matrix");
            }
            System.err.println("Finish Loading!");
            watch.reset();
            watch.start();

            /**
             * FIXME make this a command line option.
             */
            int supportThreshold = 6;

            LinkGraphClustering clustering = new LinkGraphClustering(supportThreshold, linkMatrix);
            // clustering.testSerilizable();
            if (this.writeClusteringTree) {
                clustering.run();
                clustering.saveToFile(this.treeFile);
            } else {
                clustering.readTreeFromFile(this.treeFile);
            }
            ObjectArrayList savedClusters = clustering.selectClustersToSave(20);
            GraphViewer gviewer = new GraphViewer(savedClusters, true, linkMatrix);
            gviewer.run();

            ObjectArrayList leafNodes = new ObjectArrayList();
            // for(int i = 0; i < savedClusters.size(); i++){
            // //if(i < 3) continue;
            // TreeNode clusterRoot = (TreeNode) savedClusters.get(i);
            // leafNodes.clear();
            // LinkGraphClustering.collectTreeNodes(leafNodes, new ObjectArrayList(), clusterRoot);
            // System.err.println("Cluster"+(i+1)+"_" + leafNodes.size() +" :");
            // GraphVisualization graphVisualization = new GraphVisualization(leafNodes.toList().toArray());
            // if(i == 6 || i == 7)
            // graphVisualization.run();
            // }

            // Select clusters for frequent linkset finder
            TreeNode testNode = clustering.selectClusterWithMaximalBits(supportThreshold);
            leafNodes.clear();
            // testNode = clustering.selectMaximalCluster();
            LinkGraphClustering.collectTreeNodes(leafNodes, new ObjectArrayList(), testNode);
            GraphViewer gviewer1 = new GraphViewer(leafNodes, false, linkMatrix);
            gviewer1.run();
            FrequentLinkSetFinder freFinder = new FrequentLinkSetFinder(supportThreshold, linkMatrix);
            freFinder.find(leafNodes);
            watch.stop();
            log.info("Spend " + watch.getTime() / 1000 + " to Generated " + FrequentLinkSetFinder.nodeNum
                    + " nodes");
            /*
             * MetaLinkFinder.saveLinkMatrix("linkMatrix.txt", 6); System.err.println( "Output some stats" );
             * MetaLinkFinder.outputStat(); interactiveQuery();
             */
        } catch (Exception e) {
            log.error(e);
            return e;
        }
        return null;
    }

    /**
     * @param args
     */
    public static void main(String[] args) {
        MetaLinkFinderCli linkFinderCli = new MetaLinkFinderCli();
        StopWatch watch = new StopWatch();
        watch.start();
        try {
            Exception ex = linkFinderCli.doWork(args);
            if (ex != null) {
                ex.printStackTrace();
            }
            watch.stop();
            log.info(watch.getTime());
        } catch (Exception e) {
            throw new RuntimeException(e);
        }
    }

    /* (non-Javadoc)
     * @see ubic.gemma.util.AbstractCLI#getCommandName()
     */
    @Override
    public String getCommandName() {
        // TODO Auto-generated method stub
        return null;
    }

}