The following code shows how to create nested column layout.
<!--<!-- ww w . j a v a 2s .com-->
revised from http://stackoverflow.com/questions/14418998/bootstrap-alignment-issues
-->
<!DOCTYPE html>
<html>
<head>
<link rel="stylesheet" type="text/css"
href="http://netdna.bootstrapcdn.com/twitter-bootstrap/2.2.2/css/bootstrap-combined.min.css">
<style type='text/css'>
.b {
border: 1px solid #ccc;
padding: 10px;
}
</style>
</head>
<body>
<div class="container-fluid" style="margin-top: 20px;">
<div class="row-fluid">
<div class="span9 b">
<div class="row-fluid">
<div class="span8 b">Highlighted Comic</div>
<div class="span4 b">Latest Artwork</div>
</div>
<div class="row-fluid">
<div class="span8 b">Latest</div>
<div class="span4 b">Hot</div>
</div>
</div>
<div class="span3 b" style="height: 300px;">Search</div>
</div>
</div>
</body>
</html>